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PRSS41 serine protease 41 [ Homo sapiens (human) ]

Gene ID: 360226, updated on 17-Sep-2024

Summary

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Official Symbol
PRSS41provided by HGNC
Official Full Name
serine protease 41provided by HGNC
Primary source
HGNC:HGNC:30715
See related
Ensembl:ENSG00000215148 AllianceGenome:HGNC:30715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TESSP1
Summary
Predicted to enable sodium channel regulator activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See PRSS41 in Genome Data Viewer
Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2798470..2805304)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2819044..2825877)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2848471..2855305)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene serine protease 33 Neighboring gene small nucleolar RNA, H/ACA box 3C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2852262-2853224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2861337-2862067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2862068-2862797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2864940-2865440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2870033-2870534 Neighboring gene serine protease 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2870535-2871034 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
  2. Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Bagci H, et al. Nat Cell Biol, 2020 Jan. PMID 31871319
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in intracellular organelle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease 41
Names
protease, serine 41
putative serine protease 41
testis-specific serine protease 1
NP_001341515.2
NP_001382429.1
NP_001382430.1
NP_001382431.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354586.3 → NP_001341515.2  serine protease 41 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC092117, BN000124
    UniProtKB/Swiss-Prot
    Q7RTY9
    Conserved Domains (1) summary
    cd00190
    Location:55 → 295
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001395500.1 → NP_001382429.1  serine protease 41 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS92091.1
    UniProtKB/TrEMBL
    A0A6I8PU99
    Related
    ENSP00000501492.1, ENST00000674256.1
    Conserved Domains (1) summary
    cd00190
    Location:71 → 311
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. NM_001395501.1 → NP_001382430.1  serine protease 41 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS92090.1
    UniProtKB/TrEMBL
    A0A6Q8NYF4
    Related
    ENSP00000492058.2, ENST00000399677.5
    Conserved Domains (1) summary
    cd00190
    Location:42 → 282
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. NM_001395502.1 → NP_001382431.1  serine protease 41 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC092117
    Conserved Domains (1) summary
    cd00190
    Location:42 → 181
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2798470..2805304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2819044..2825877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7RTY9.1 GenPept UniProtKB/Swiss-Prot:Q7RTY9

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials